Wednesday, December 26, 2012

How to Become a Car Designer | Sports?Motorbikes, Bikes ... - blog

You can earn your bachelor follow to go for your master. You can get your degree in graphic design, furniture design, architectural design, or interior design and then go for a Masters in automotive design. This path would be appropriate if you are making a career change an area of the design to another. Whichever route you choose, look for a school that offers computer-aided design (CAD) courses and has connections with the departments of automotive design one or more automakers. You can also find a school closer to where you currently live as possible, although this is not a practical requirement if you want to attend a series of automotive design program. You can expect to spend three to four years looking for a Bachelor or industrial design or automotive design. Control programs can work even 2-4 years.

You may want to consider going for your master?s degree in automotive design to get a better starting position, treatment or give you an advantage in a tight labor market. This is a difficult situation. You are 16 years old and desperate to become a car designer but have no idea on how to achieve this ambition burn. Well, discovering Car Design News is a good start, but if you are serious about training as a designer to work in a major car studio then you need to do a course in Transportation Design, an industrial design agency (sometimes known as Product Design). While several hundred design schools around the world organize courses industrial design, only around 20 wordwide offer courses that specialize in Transportation or Automotive Design and most of those are listed in the Careers section of the site CDN.

Car design has always been one of the most competitive careers in design around and the fight begins to get a place on one of these courses. The competition for places is fierce and schools can often afford to choose the best candidates. Simply send in an application is not enough; in addition, you will need a good portfolio of work to back up your application. Among the variety of courses offered, you must select one that suits your needs. Obviously, a school that is close enough to where you live is a starting point, but maybe not so easy if you?re outside a region where land is situated. Philosophy and reputation of the training and faculty are also important factors.

Some schools have close ties with automakers near or in the automotive industry, where practicing designers will be involved on a part-time basis or for sponsored projects. Some of them have a strong bias engineering; others may have more impressive modeling and workshop equipment or access studios 24 hours. It is important to visit some exhibitions academic degrees and speak to the students of the school to find out what the course entails what the classes are like and contact the applications department early on. Many schools have open days and arrangements to visit one of these days are strongly recommended prior to any decision.

Source: http://www.gladsite.com/2012/12/how-to-become-a-car-designer/

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Ability to metabolize tamoxifen affects breast cancer outcomes

Dec. 26, 2012 ? For nearly a decade, breast cancer researchers studying the hormone therapy tamoxifen have been divided as to whether genetic differences in a liver enzyme affect the drug's effectiveness and the likelihood breast cancer will recur. A new study by researchers from the Mayo Clinic Cancer Center and the Austrian Breast and Colorectal Cancer Study Group provides evidence that genetic differences in the enzyme CYP2D6 play a key role in how well tamoxifen works.

"Our findings confirm that, in early breast cancer treated with tamoxifen, genetic alterations in CYP2D6 lead to a higher likelihood of recurrence and death," says Mayo Clinic oncologist Matthew Goetz, M.D., lead author of the study in the journal Clinical Cancer Research.

In the clinical trial, Dr. Goetz and his colleagues studied the rates of cancer recurrence and death in two groups: postmenopausal women with primary estrogen receptor-positive breast cancer who received tamoxifen for five years and those who received tamoxifen for two years followed by the aromatase inhibitor anastrozole for three years. Anastrozole is a breast cancer drug whose metabolism does not require the CYP2D6 enzyme.

The study showed that women who were born with genetic alterations of CYP2D6 that abolish the enzyme's critical metabolizing activity and who took tamoxifen for five years had recurrence of breast cancer, or died at a rate 2.5 times higher than women with normal CYP2D6 enzyme activity. Women with intermediate levels of the CYP2D6 enzyme had rates of recurrence or death 1.7 times higher than women with normal CYP2D6 activity. Importantly, Dr. Goetz notes, that genetic alterations in CYP2D6 did not affect the likelihood of recurrence or death in women who switched to anastrozole after two years of tamoxifen.

"Switching from tamoxifen to an aromatase inhibitor may be one reason for the discrepant studies surrounding CYP2D6 and tamoxifen -- as information about whether a patient took an aromatase inhibitor after tamoxifen was not available in most of the prior studies," says senior author James Ingle, M.D., of Mayo Clinic, an expert on hormone therapies for breast cancer.

A blood test can determine whether a woman has alterations in CYP2D6 and predict how efficiently her body will convert tamoxifen to endoxifen. Approximately 5 to 7 percent of European and North American populations are considered poor metabolizers of tamoxifen.

"The results of this successful high-level international research collaboration are an important step forward in our quest to individualize breast cancer treatment and provide tailored care to women with breast cancer," says Michael Gnant, M.D., professor of surgery at the Medical University of Vienna and president of the Austrian study group.

So what should a woman do if she is unable to effectively metabolize tamoxifen into its most active form? Dr. Goetz believes that the current recommendation of switching from tamoxifen to an aromatase inhibitor is likely to result in the greatest benefit in women with decreased CYP2D6 metabolism. For CYP2D6 poor metabolizers, avoiding tamoxifen altogether and starting out with an aromatase inhibitor may be the best approach, he says.

Dr. Goetz's group is working with the National Cancer Institute to develop endoxifen as an alternative to tamoxifen. If women can be given endoxifen, the active part of tamoxifen, it won't matter how tamoxifen gets metabolized, he says.

The study is partially funded by the National Institutes of Health, co-authors include Vera Suman, Ph.D.; Tanya Hoskin; Mary Kuffel; Stephanie Safgren; Carol Reynolds, M.D.; Matthew Ames, Ph.D.; and Richard Weinshilboum, M.D., all of Mayo Clinic; Martin Filipits, Ph.D.; Raimund Jakesz and Margaretha Rudas of the Medical University of Vienna; Richard Greil and Otto Dietze of Paracelsus Medical University, Salzburg, Austria; and Alois Lange and Felix Offner of Medical Hospital Feldkirch, Austria.

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The above story is reprinted from materials provided by Mayo Clinic.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. M. P. Goetz, V. Suman, T. L. Hoskin, M. Gnant, M. Filipits, S. Safgren, M. J. Kuffel, R. Jakesz, M. Rudas, R. Greil, O. Dietze, A. Lang, F. Offner, C. A. Reynolds, R. M. Weinshilboum, M. Ames, J. N. Ingle. CYP2D6 Metabolism and Patient Outcome in the Austrian Breast and Colorectal Cancer Study Group Trial (ABCSG) 8. Clinical Cancer Research, 2012; DOI: 10.1158/1078-0432.CCR-12-2153

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/1Qs-o9glewA/121226153030.htm

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Tuesday, December 25, 2012

Things You Need to Know About Watercolour Painting ...

Painting with watercolours is a fascinating medium and perhaps a little more challenging than oils or acrylics. This is because such things as bleeding can occur and if you make a mistake it cannot be painted over, making it less easy to control.

That being said, painting with watercolours is a very hard choice to resist. Below you will find a few basic terms and techniques that you may find useful.

Terms Used in Watercolour Painting

Blotto Painting: using tempera paint apply it to one side of a piece of paper and then fold it in order to create a second image, the result being very similar to an ink blot.

Flat Wash: a smooth covering that is even or uniform with no shading or tint changes and is used for backgrounds or sizeable areas of the watercolour surface.

Graded Wash: is used to cover the painting surface. It is thinly or lightly coloured and is then gradually made thicker and darker in order to achieve a light to dark effect. Vice versa to achieve a dark to light effect.

Wash: a thin and normally translucent paint layer which is used in backgrounds or for covering large surface areas.

Waterbrush: A waterbrush is just like an ordinary paintbrush. It has a shaped tip made out of bristles but unlike your typical brushes, this one has a small reservoir or vat attached to it that holds water. When in use, the water flows in a slow and controlled manner to the bristles, allowing for continuous wet application.

Wet on Dry Watercolour Painting: This is watercolour painting applied to a dry surface which will bring about cleaner, sharper, more defined details/lines.

Wet in Wet Watercolour Painting: applying watercolour paint to a wet colour surface allowing for better merging, blending, bleeding, blurring, undefined lines or details.

Using quality art materials will help you to create your very own masterpiece and the purchase of quality art books will more than help too as they will give you much more information and ideas than what you see here.

Prior to painting it is necessary to prepare and stretch your paper properly. You do this by wetting and taping the paper down onto a wooden board to prevent wrinkling or buckling when applying the paint. Leave the paper to dry naturally, if possible, so you may need to start this particular process the day before you want to start your painting.

Applying a Wash to Paper

Wash your paper using clear water and a large, wide brush to dampen it. Stretch your arm out fully and move across the surface width with one continuous stroke, continuing with the same brush and colour until the surface is covered evenly. To apply a graded wash, dampen the surface, make the first complete stroke with the colour and with little water and add a slight amount of water for each successive brush stroke.

Using the Wet in Wet Technique

Paint a clean water image or shape and with the second action dip brush in watercolour and apply. The added colour will disperse, or bleed, into the wet space and to its edges. Experiment with painting a watercolour image or shape and using a second colour to add to the first to create bleeding and blending of colours.

Watercolours are versatile art materials and art books are necessary to boost your confidence. By painting with watercolours or inks you can achieve textures, shapes, brush strokes, contrast and values similar to any other painting medium. However, achieving luminosity in watercolours is much easier than with other paints.

Although many other colours are available, using black ink will restrict your work to grey scale or black and white. This can be helpful if you are just starting out or if you desire clarity and a strong composition in your art.

All you need to start painting in watercolours are art books and supplies, a willingness to learn and the mindset to succeed.

Shop 4 Books is an online bookshop for everything books and magazine subscriptions. We have a diverse range of categories covering all genres, including art books and supplies and in all major formats.

We have the lowest price books online so check us out and take advantage of all our frequent special offers.

Source: http://www.huntingbynight.com/things-you-need-to-know-about-watercolour-painting/

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How to cope with a slow connection away from home

4 hrs.

Q. ?I'm going home for the holidays, and my parents have a very slow connection. Do you have any tips for getting my work done effectively when everything's moving slower than molasses??

Separate your Internet-heavy work and postpone it?
A.?
Before you start making tweaks to your browser and computer, it's a good idea to take stock of what work you have and separate it into two categories. GigaOM explains:

Divide your tasks into bandwidth-heavy and bandwidth-light. Evaluate your routine web tasks and see which ones you can do with a slow connection, and which ones require a faster, more reliable one. This is especially important if your mobile Internet provider charges based on bandwidth usage instead of time. Aliza Sherman did something similar in a previous post, to help her work around bandwidth limits.

This is particularly useful if you know you're going to be stuck on a slow connection, but even if you get yourself in a bind, you can still do some re-prioritization quickly. If you have some Internet-heavy tasks that can't wait, you should delegate them to someone else if you can???heck, even offer to pick up some of your co-workers' Internet-light load if they can help you out.

Tweak your browser for low-speed connections
Chances are, your browser isn't exactly primed for slow Internet speeds. So, we recommend grabbing a second browser that you can tweak to work better with slow connections. Opera is a great choice, because it has a Turbo Mode that optimizes the Web for faster loading, but no matter what, there are a number of tweaks you can make to speed up your browser, like:

With these few tweaks in place, you should find things run a little smoother and you won't be stuck waiting for pages quite as long.

Use mobile, HTML or other low-footprint sites
These days, a lot of websites load up their pages with junk that isn't really a problem when you have a normal high-speed connection, but can really bog things down when your connection is limited. Some of them have alternatives in place.?

Gmail, for example, has a handy HTML version that you can use to cut down on the crap when you need to get into your email quicker. You can also see if a specific site has a mobile version, designed for smartphones. Most mobile sites will only load if you're actually on a mobile device, though, so you'll want to change your browser's user agent to make sites recognize you as a smartphone.

Work outside your browser whenever possible
The?more you stay in your browser, the longer you'll be waiting for pages to load. Travel website Gadling recommends transferring as much of that work outside your browser as possible. For example, if you write on a blog or do any work in Google Docs, transfer that to a desktop app like Microsoft Office or LibreOffice for the time being. Heck, you can even compose an email in Notepad while you wait for it to load???don't waste any time watching a progress bar when you could be doing something else.

When you do have to work in your browser, try not to put too much stress on it. Open one tab at a time, so you aren't trying to load a bunch of pages at once (since it'll take them longer, and you can only read one at a time). Close tabs you aren't using often, as they can often take up bandwidth even if you aren't looking at them.

Turn off bandwidth-sucking background apps?
With all the focus on your browser, you may forget that other apps like Dropbox might be taking up precious bandwidth in the background. Close any and all of those you don't need to do your work, or put them into offline mode so they aren't constantly checking if they need to sync. Some apps may require some foresight for this to work: Notational Velocity and ResophNotes will work fine without a connection, for example, but Evernote will require you to go into its settings and download your notebooks before it'll work in offline mode.

When all else fails, find better Wi-Fi?
No one wants to rush around all day trying to find better Internet, but if what you're using is just too slow, look elsewhere. Free Wi-Fi is everywhere, and if at first you don't succeed, find a faster hotspot. You won't be able to do this all day if you have work to get done, but you should be able to find something that's somewhat workable for the time being.

More from Lifehacker:

Source: http://www.nbcnews.com/technology/technolog/how-deal-slow-internet-connection-away-home-1C7660214

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Generate Internet Traffic for Your Home Business | TLP India

In terms of driving internet traffic to your home business, you have an almost unlimited amount of choices. You can get products on Clickbank, purchase guru training programs, and offline courses.

If you?re in the home based business industry, getting traffic to your site will allow you to generate leads for your home business on autopilot. This means you?ve got more exposures and targeted traffic viewing your business opportunity. So, even if you?re an inadequate prospector and don?t have the closing skills of many of the top dogs in the business, you may still get commissions and sales when you are able to drive plenty of traffic to your online site.

Would getting 1000 visitors per day improve your business? Obviously it would. How much would that traffic mean to your business? What if you could add an extra sale a week, and you did that each week? Think of the extra income you?d create at the end of each month.

You have to learn how to drive a regular stream of top quality leads to your site, because company replicated sites and lead capture pages do not rank well on the search engines, how do you create an online business that drives leads through quality content?

Content is the new currency, but anybody can create content. The real key to getting visitors is exactly what you do when you finally develop your content.

1. Have a plan:

For those who really need to get more long-term traffic, you should have a plan. When you have an advertising plan that enables you to routinely push traffic towards your site, you can build an email list, increase front-end sales, that will create residual income through your marketing efforts

2. Focus on repeat traffic:

Repeat visitors are the very best traffic. Usually, a visitor to your blog won?t purchase something from you the very first time they land on your blog. The truth is, it might take up to a dozen times before they even consider investing in a product you promote or suggest to your potential customers. But, how will you capitalize on the traffic you?re able to boost the chances of recurring visits that will potentially maximize your income?

The critical step is allowing your visitors to warm-up to you. By doing this they trust you more. When you post valuable and useable content to your site on a daily basis, individuals will grow to listen and trust your suggestions and recommendations.

3. Leverage social media:

There are lots of methods to drive traffic on the Internet, and all network marketers in this era will need to have a social media marketing strategy. Take into account how you are marketing online. Are you currently hoping people see you, or are you marketing with intention and building relationships with your potential audience?

Day-to-day you?ll want to post to Facebook groups that are designed for your audience. Again, the important thing would be to post blog content, not spam your links or business opportunity. In a sea of amateur marketers, this enables you to stand out from the crowd and attract those people who are hungry to explore how you can help them build their business bigger, faster and better.

Find out whom you want to target, create content that serves them, and you will get them to visit your site.

Learn more about internet traffic. Stop by Cory Clemons?s site where you can find out all about web traffic and what it can do for your blog or website.

Tags: internet traffic, Marketing, traffic

Source: http://tlpindia.com/generate-internet-traffic-for-your-home-business/

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Why America's Money Is the Best Money

The next time you're tempted with jealousy over the brightly colored currency of other countries, just take this one look at what our beloved dollar bill would look like in technicolor. It looks like what the Joker plays Monopoly with. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/pPcKwdUZ-Ag/why-americas-money-is-the-best-money

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The States Doling Out the Best (And Worst) Benefits

24/7 Wall St. :

With the president and Congress attempting to reach a budget deal in an effort to avoid the fiscal cliff, it is likely they will agree on spending cuts, including those to entitlement programs. If they do not reach a deal in time, the nation may stumble into another recession triggered by the automatic austerity measures related to the fiscal cliff. Either way, there is almost no doubt that social programs and other spending will be cut in some way. The latest offer on the table includes the elimination of unemployment insurance for hundreds of thousands of Americans, as well as longer-term reductions in Social Security.

Read the whole story at 24/7 Wall St.

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Source: http://www.huffingtonpost.com/2012/12/24/the-states-doling-out-the_n_2359598.html

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Monday, December 24, 2012

Memorial service for Sen. Inouye held in Hawaii

HONOLULU (AP) ? The late Sen. Daniel Inouye was remembered Sunday as an American hero whose legacy as a war veteran and longtime senator would be felt across Hawaii for years to come.

The memorial service at Honolulu's National Memorial Cemetery of the Pacific was attended by more than 1,000 people, including President Barack Obama, Senate Majority Leader Harry Reid, Hawaii's congressional delegation and a number of other senators, cabinet secretaries and other dignitaries.

"Daniel was the best senator among us all," Reid told those assembled. "Whenever we needed a noble man to lean on, we turned to Sen. Dan Inouye. He was fearless."

The cemetery is the final resting place to thousands of World War II veterans. More than 400 members of the storied Japanese-American 442nd Regimental Combat Team ? of which Inouye was a part ? are buried at the site.

Several 442nd veterans attended the Sunday morning service, the latest in a number of tributes and honors for Inouye following the 88-year-old's Dec. 17 death from respiratory complications.

A 19-gun cannon salute was fired as Inouye's coffin arrived at the cemetery. The service also featured a flyover by F-22 military jets and the playing of "Taps" by Democratic Sen. Jon Tester of Montana.

Inouye's widow, who was seated with the president and first lady Michelle Obama in the front row, dabbed her eyes as a pipes and drums band played "Danny Boy."

Inouye was the first Japanese-American elected to both houses of Congress and the second-longest serving senator in U.S. history.

He was a high school senior in Honolulu on Dec. 7, 1941, when he watched dozens of Japanese planes fly toward Pearl Harbor and other Oahu military bases to begin a bombing that changed the course of world events.

He volunteered for a special U.S. Army unit of Japanese-Americans and lost his right arm in a battle with Germans in Italy. That scratched his dream of becoming a surgeon and he went to law school and into politics instead.

"He was a shining star of the greatest generation," fellow Hawaii Democratic Sen. Daniel Akaka said at the service.

Akaka also highlighted Inouye's role in steering federal money to build roads, schools and housing in Hawaii over the decades, from the beginning of statehood.

"Dan Inouye is Hawaii and Hawaii is Dan Inouye," Akaka said.

Several services have already been held in Washington and in Hawaii for Inouye. He lay in state at both the U.S. Capitol Rotunda on Thursday and the Hawaii state Capitol on Saturday.

Obama eulogized Inouye during a service at Washington's National Cathedral on Friday, saying that Inouye's presence during the Watergate hearings helped show him what could be possible in his own life.

The president arrived early Saturday in Honolulu for his annual Christmas family vacation. He made a brief visit to the grave of his grandfather, World War II veteran Stanley Dunham, after Sunday's service.

___

Connect with Becky Bohrer at https://twitter.com/beckybohrerap

Source: http://news.yahoo.com/memorial-sen-inouye-held-hawaii-210150345--politics.html

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Sunday, December 23, 2012

History of gun-control legislation (Washington Post)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/272632678?client_source=feed&format=rss

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If You Are Looking For An Automated Program To Earn Money ...

If You Are Looking For An Automated Program To Earn Money Online You Might Want To Read This

There are plenty of different methods to begin earning money online but you are going to see that many men and women want to try and find an automated way in order to do this. While there are lots of programs that can show you how to make money online you are going to discover that there are extremely few programs that claim to be able to do this automatically for you. Something you should be conscious of is that a few of these programs are nothing much more than scams that will not ever work, but a few may be able to begin earning you some cash. In the following paragraphs we are going to be explaining a number of the things you should be looking for when deciding to choose an automated program for earning cash online.

Any successful Online Marketer will tell you that there are particular things that are absolutely required for folks to end up becoming successful in their web based business. Three of the items are absolutely required when it comes to making cash on the web is a good selling product, the means to sell this product and also traffic. For individuals who definitely want an automated program you?re going to find that these three requirements are going to have to be something that this program can provide for you, otherwise it will not be worth it.

Building an e-mail list is something which most successful Web Marketers do, of course, if you find a good automated program which will help you with this you?ll be well ahead of the game. There are successful Internet Marketers out there today that do not have an e-mail list, but you will find that success without one will be rare. If the program is unclear about list building you can always feel free to contact them and figure out if this is part of their program and just how it works.

Whether or not you?ll be advertising affiliate links or your own website is one more thing you may want to find out about before you buy the program so you know what you are in store for. Even though promoting affiliate links would be fine, most Web Marketers will recommend you have your own website that you are driving traffic to rather than driving traffic straight to affiliate links. Affiliate marketing programs can often close down with no notice whatsoever, which means all of the work you have done in order to market this has been wasted. For individuals who have your own sites, I am sure you comprehend that if one affiliate program closes you are able to merely replace it with a different one.

The very last thing you should be looking for is some sort of guarantee that the program will achieve success or they?re going to give you your cash back. The tips that we detailed here should be able to help you in deciding whether an automated program is worth the investment or not.

Online MLM is a great internet business option. If you are looking for online Network Marketing Tips visit this video by clicking here

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Source: http://www.businesslistingnow.com/blog/if-you-are-looking-for-an-automated-program-to-earn-money-online-you-might-want-to-read-this/

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Mitt Romney ?had no desire to run,? son says

Mitt Romney hugs his son, Tagg, at a campaign stop. (AP/File)

Mitt Romney didn't want to be president, anyway.

That's what Tagg Romney, Mitt's oldest son, told the Boston Globe for its big post-mortem on his father's failed presidential bid published on Sunday.

?He wanted to be president less than anyone I?ve met in my life," Tagg Romney told the paper. "He had no desire to ... run. If he could have found someone else to take his place ... he would have been ecstatic to step aside.

"He is a very private person who loves his family deeply and wants to be with them," Tagg continued. "He has deep faith in God and he loves his country, but he doesn?t love the attention.?

Romney's reluctance to become commander in chief has been hinted at by his sons before. Before their father sought the 2012 GOP nomination, several said they tried to convince him not to run.

"I tried to convince him not to," Matt Romney told Conan O'Brien in June. "I think there were a few of us that tried that. I just felt for us as a family, this isn't the best thing. But ... for the country, we think it's the right thing."

Source: http://news.yahoo.com/blogs/ticket/mitt-romney-no-desire-president-tagg-says-191236665--election.html

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Saturday, December 22, 2012

Mother loses UK legal fight to stop son's cancer radiotherapy

LONDON (Reuters) - A mother in Britain, who was so desperate to stop her cancer-stricken son having to undergo conventional medical treatment that she went into hiding with him, lost a court battle on Friday to prevent him receiving radiotherapy.

The case of Sally Roberts, 37, a New Zealander living in Brighton, southern England, and the plight of her seven-year-old son has made headlines in Britain.

Roberts wants to try alternative treatments first, including immunotherapy and photodynamic therapy for her son Neon. She has been told the boy needs treatment fast but fears the side-effects of conventional medicine.

Doctors treating the boy had warned that without radiotherapy he could die within three months

Judge David Bodey told the High Court in London the life-saving radiotherapy treatment could start against the mother's wishes, the Press Association reported.

"The mother has been through a terrible time. This sort of thing is every parent's nightmare," the judge said.

"But I am worried that her judgment has gone awry on the question of the seriousness of the threat which Neon faces."

The story of the sick blue-eyed blonde boy came to public attention earlier this month when Roberts prompted a nationwide police hunt by going into hiding with Neon for four days to stop him from undergoing the treatment.

The mother's relentless battle in court also cast a light on the dilemmas parents can face when dealing with the illness of a loved one, considering the short-term and long-term risks of a treatment and handling conflicting medical information available at the click of a mouse.

Roberts said in court she had researched on the Internet her son's condition - a fast-growing, high-grade brain tumor called medulloblastoma - and sought advice from specialists around the world because she did not trust British experts.

She feared radiotherapy would stunt the boy's growth, reduce his IQ, damage his thyroid and potentially leave him infertile.

Earlier this week, a judge ruled that Neon could undergo emergency surgery to remove a tumor which had resisted an initial operation in October, despite opposition from his mother, who found he appeared to be recovering after what she said was a "heartbreaking" stay in hospital.

"EXPERIMENTAL AND UNPROVEN"

Surgeons said Neon's operation on Wednesday had been successful but that radiotherapy was needed to ensure no residual tumor was left behind.

Neon's father Ben, who lives in London and is separated from Roberts, has sided with his son's doctors.

But his wife suggested exploring several alternative treatments, including immunotherapy, which mainly consists of stimulating the body's immune system to fight cancerous cells, and photodynamic therapy, which uses a photosensitizing agent and a source of light to kill malignant cells.

The hospital treating Neon slammed "experimental and unproven" methods which entered "unchartered territory". The hospital, which cannot be named, also questioned the credentials of some of the private specialists contacted by Roberts's team.

The court heard that at least one of these could not even correctly spell medulloblastoma.

Radiotherapy is used to prevent cancer from spreading or striking back after surgery but it can damage nerve tissue and healthy brain cells.

Long-term side effects tend to be more common in children, whose nervous systems are still developing.

(Reporting by Natalie Huet; Editing by Sophie Hares)

Source: http://news.yahoo.com/mother-loses-uk-legal-fight-stop-sons-cancer-170325898.html

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Take a closer look at Benson Henderson?s win over Nate Diaz (VIDEO)

Take a closer look at UFC on Fox 5's main event through Fuel TV's Fight Flashback. It shows how champion Benson Henderson and challenger Nate Diaz prepared moments before their fight, as well as different angles of the bout. Nick Diaz, Nate's brother and also a UFC fighter, winces as he watches his brother get kicked. You'll also hear advice from both men's corners, including Henderson's saying, "You know why he's talking, right?"

You can also see the same treatment for other bouts on the card here.

Source: http://sports.yahoo.com/blogs/mma-cagewriter/closer-look-benson-henderson-win-over-nate-diaz-150036538--mma.html

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These Weird Cartoon Faces Are All Drawn By an Algorithm

There's a certain aspect of human creation, a quaint sort inconsistent imperfection, that most of us tend to think is exclusive to us meatbags. Turns out it's not; computers can emulate that too, and these weird-looking cartoon faces you could swear were drawn by a five-year-old prove it. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/wVinztDwy80/these-weird-cartoon-faces-are-all-drawn-by-an-algorithm

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Friday, December 21, 2012

Poll: If you worked for Google, which corporate gift would you pick?

If you worked for Google, which corporate gift would you pick?

Gift-giving is a beautiful thing, but it inevitably sets precedents. Last Christmas, Google's employees were each handed a customized Galaxy Nexus to take home, which means they'll be expecting something just as nice this year. One solution would be the Nexus 4, but Mountain View is far too smart to let its festive joy hinge on LG's supply chain. Instead, it's apparently taking the safer route of letting workers choose for themselves: either the excellent Nexus 7 (it's not clear which capacity, but we'd guess 32GB) or a wonderful new Samsung Chromebook, or a recently Jelly Beaned RAZR M. So go on, tell us, if all the right hypotheticals were in place, which would you pick?

View Poll

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Source: The Next Web

Source: http://www.engadget.com/2012/12/21/google-corporate-gift-poll/

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NCAA Duke Blue Devils 8GB High-Speed USB Flash Drive with Swivel Cap and Lanyard

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96% Chasing Ice

All Critics (56) | Top Critics (19) | Fresh (54) | Rotten (2)

The most important documentary of the year.

"Chasing Ice" is a grand adventure, a visual amazement and a powerful warning.

If you're looking for eye-popping evidence that the world's glaciers are melting, don't miss the small-scale but spectacular documentary, Chasing Ice.

The rapid disappearance of ice mountains, filmed over a period of years, is compressed through time-lapse technology into minutes and seconds. The speeded-up effect is harrowing and also, disturbingly, eerily beautiful.

The movie might have given us a bit less of Balog and a bit more of the startling sequences he produced.

Though the filmmaker's point of view on the matter seems quite clear, Orlowski does smartly acknowledge counterarguments against climate change without dwelling on them.

While skeptics continue to doubt global warming is a man-made phenomenon - Rush Limbaugh called warnings about it "garbage science" - "Chasing Ice" leaves little doubt it is occurring.

It's an absorbing and vital watch.

It's like watching our world disappear.

A few scientists pop their heads in here, a few charts are deployed, but Chasing Ice is powered primarily by the imagery, stark, irrefutable evidence that the planet is warming, not in one or two isolated places but everywhere.

"Chasing Ice" is a beautiful film to watch, especially on the big screen. But the documentary's visual pleasures come with a heavy dose of guilt.

It's sobering stuff but the film's impact is somewhat diminished by Orlowski's reverential profile of Balog, who continues to crusade despite the toll his endeavours have taken on his body.

The documentary feels a little slight but the images speak for themselves ...

Is this about the hazards of global warming or the awesomeness of James Balog? Not entirely sure...

If any film can convert the climate-change sceptics, Chasing Ice would be it: here, seeing really is believing.

While more detailed scientific analysis and greater discussion of impacts would have been welcome, the film's visual rhetoric is solid.

National Geographic photographer James Balog illustrates climate change with time-lapsed records of glacial retreat.

A project of heroic, Herzogian endeavour. Mad, you might say. But probably not as mad as what the rest of us are doing about climate change: namely almost nothing.

Utterly engaging in its demonstration of the planet's shocking climate change and is thoroughly absorbing to watch.

Chasing Ice is a uniquely visual adventure with a chilling message warmed by Balog's humanity.

Still an eco-sceptic? Clap your eyes on this lot. Awe-inspiring, terrifying, transcendently beautiful, and absolutely weighted with significance for the future of the planet.

This is a well made Documentary that becomes very involving because it's just as much about Balog's journey as it is about global warming.

Makes a convincing case that the story of climate change is best told by pictures, not words.

Despite its dire message about rising carbon dioxide levels polluting the Earth, Chasing Ice is a beautiful film, with stunning visits to snowy realms with deep blue water.

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Source: http://www.rottentomatoes.com/m/chasing_ice_2012/

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Thursday, December 20, 2012

Better stroke care, everywhere: Study boosts local hospitals' clotbuster use

Dec. 20, 2012 ? From the moment a stroke occurs, patients must race against the clock to get treatment that can prevent lasting damage. Now, a new study shows the promise -- and the challenges -- of getting them state-of-the-art treatment safely at their local hospital, saving precious minutes.

The results come from an effort that tested methods to improve delivery of a time-sensitive, clot-busting drug in stroke patients at 24 community hospitals across Michigan. To date, clot-busting treatment has been mostly used at larger hospitals.

The research effort was coordinated by members of the University of Michigan Health System's Department of Emergency Medicine, Department of Neurology and Stroke Program, which offered half the hospitals education and round-the-clock treatment assistance by phone. The study was funded by the National Institute of Neurological Disorders and Stroke at the National Institutes of Health.

By the end of the study, the community hospitals across Michigan that had the U-M experts as the "sixth man" on their teams did better at delivering the drug called tPA to eligible patients than those that didn't.

The findings of the randomized controlled trial are published in Lancet-Neurology. They show that community hospitals can indeed improve patients' chances of getting tPA in the first few hours of a stroke, without increased risk of dangerous bleeding.

Data from 22 of the hospitals show that tPA use more than doubled in the 11 hospitals that were randomly chosen to get the extra help, versus a smaller increase in the 11 that didn't. Some hospitals even surpassed national targets for tPA use that large stroke centers don't always reach -- a true game-changing performance.

Across the U.S., less than 2 percent of stroke patients receive tPA -- when more than 11 percent could -- largely because of the time limits on its use and delays in getting patients to a hospital. That's why it's important for community hospitals to offer it.

The investigation, called INSTINCT for INcreasing Stroke Treatment through INterventional Change Tactics, demonstrates that tPA can be used safely and appropriately in the community hospital setting -- and that more work needs to be done to expand public access to the only treatment approved by the U.S. Food and Drug Administration to reverse the effects of stroke. While improvement at the target community hospitals that got the education was statistically significant, it was not as large as hoped for. But the findings suggest that relatively low-cost and low-tech interventions can improve local stroke care.

Lead author Phillip Scott, M.D., a U-M emergency physician and principal investigator of the trial, likens the results to the performance of teams from smaller athletic conferences that beat larger, more celebrated teams, to reach the final stages of the annual NCAA college basketball tournament.

"This study suggests that community hospitals can evaluate and treat enough emergency stroke patients to keep their teams' treatment skills sharp, but are of a size that creates rapid lines of communication and stable physican and nurse teams. This may facilitate rapid, safe stroke diagnosis and care," says Scott, an associate professor of emergency medicine at the U-M Medical School. "Four of the hospitals that received the educational intervention achieved tPA use rates of 5 to 8 percent of all stroke patients, compared to only one of the control hospitals. That's a rate many large medical centers strive to reach."

"This study, while finding only modest improvements, provides encouraging evidence that intensive professional education at community hospitals has the potential to improve the use of tPA in acute stroke care," said Scott Janis, Ph.D., program director at the NINDS. "Importantly, it also lays the groundwork for future strategies that should be explored to develop evidence-based interventions that would improve patient access to this proven therapy following stroke."

How it was done, and more about the results:

The study started by collecting baseline data on stroke treatment from 2005 and 2006 at all the hospitals. After the sites were randomized, the U-M team offered continuing medical education classes at the hospitals, workshops at U-M, and other support, including 24-hour phone consultation availability, to the hospitals chosen to receive the intervention.

All the hospitals were in the lower peninsula of Michigan, and were chosen at random from among hospitals with at least 100 stroke discharges per year. All hospitals that participated stayed in the trial until data collection ended in 2010. Hospitals could hold primary stroke center designation, as granted by the Joint Commission, but could not be tertiary academic comprehensive stroke centers.

In all, 188 tPA treatments occurred among 15,065 stroke patients during the baseline period, and 557 treatments occurred among 25,758 stroke patients from 2007 to 2010. The authors note that tPA use at hospitals nationwide rose somewhat during the study period, due to factors such as insurance reimbursement and new data on tPA's effectiveness at preventing disability.

The INSTINCT study findings were complicated by the fact that one of the hospitals enrolled in the trial became an academic stroke center after starting the study. When it and its matched hospital are excluded from the analysis, the remaining hospitals showed enough of an impact from the educational effort to be statistically significant -- a 105 percent increased use of tPA over baseline.

"We essentially saw a doubling of tPA usage, using standard technologies for education and support. Importantly, the increase was achieved safely," Scott says. "This shows we can translate the knowledge of effective stroke treatment into a community setting." The size of the study, with 557 stroke patients treated after intervention began, makes it one of the largest tPA studies in the world.

More about stroke treatment:

The use of tPA in ischemic stroke has grown around the world in the last decade, but many patients who could get the drug still do not. The "treatment window" for tPA has been seen as three hours from the onset of stroke symptoms, though recent studies suggest patients can see benefit even four and a half hours out. The importance of early treatment, however, cannot be overstated, as patients treated earlier have greater benefits and the drug is not currently FDA-approved for use beyond three hours.

Considering that most stroke sufferers wait more than an hour after symptoms start before they seek help, and that travel time to a tPA-providing hospital is around 30 minutes, that leaves hospitals about an hour to do medical imaging, make a firm diagnosis and initiate tPA treatment.

Patients must then be monitored to check for brain bleeding, and to assess the impact of their stroke. To reliably accomplish this, a system for the care of acute stroke patients must already be in place when a patient arrives at the emergency department.

Patients who don't reach a location where they can received standard tPA treatment in time can still potentially be treated with advanced catheter-based clot removal treatment at a major referral hospital such as U-M. These advanced therapies have a longer time window for treatment, but have not been proven more effective than early standard treatment. The Stroke Program at U-M is participating in multiple trials to improve advanced stroke treatment.

Additional authors: William Meurer, M.D., Shirley Frederiksen, M.S., and Robert Silbergleit, M.D. of U-M Emergency Medicine; John Kalbfleisch, Ph.D., Zhenzhen Xu, Ph.D. and Mary Haan, DrPH of the U-M School of Public Health; and Lewis B Morgenstern, M.D., of U-M Neurology. Morgenstern directs, and Scott, Meurer, Frederiksen and Silbergleit are members of, the U-M Stroke Program.

Funding source: NINDS R01-NS-050372

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Story Source:

The above story is reprinted from materials provided by University of Michigan Health System.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Phillip A Scott, William J Meurer, Shirley M Frederiksen, John D Kalbfleisch, Zhenzhen Xu, Mary N Haan, Robert Silbergleit, Lewis B Morgenstern, for the INSTINCT Investigators. A multilevel intervention to increase community hospital use of alteplase for acute stroke (INSTINCT): a cluster-randomised controlled trial. The Lancet Neurology, 21 December 2012 DOI: 10.1016/S1474-4422(12)70311-3

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/AjYeIT4_oEI/121220195754.htm

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Brooks PureDrift Review: Shoes for Minimalists Pushing Mileage

When you're running "barefoot style," you have be be careful as you're building strength. Try to run too far or too fast in minimal shoes, and you could really hurt yourself. Brooks' all-new PureDrift is yet another shoe designed to bridge the gap between cushioning and minimalism. Let's see if it can succeed where others have failed. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/EHRLSKecMG0/brooks-puredrift-review-shoes-for-minimalists-pushing-mileage

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Ask Lifehacker Live on Google+ Hangouts: The Entire Lifehacker Staff Is In [UPDATE: DONE]

Ask Lifehacker Live on Google+ Hangouts: The Entire Lifehacker Staff Is In [UPDATE: DONE]Ask Lifehacker Live on Google+ Hangouts: The Entire Lifehacker Staff Is In [UPDATE: DONE] For the next hour, everyone at Lifehacker will be on Google Hangouts to answer your most pressing questions. You'll be able to watch us live and participate, or listen to the full Q&A afterwards. Come on in and ask your question!

Tune In

The show is over, but you can watch the recording here (or by clicking play on the video up top). We're in the process of getting the audio version together for our regular podcast listeners, so that'll be up shortly. If you tuned in (or are tuning in now) and want links to the topics we discussed, you'll find them below.

Links from the Discussion

We mentioned a lot of software and solutions in today's discussion. Here they are, should you want more information.

We'll be adding more links as we find 'em!

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/oKlxvugpiEo/ask-lifehacker-live-on-google%252B-hangouts-the-entire-lifehacker-staff-is-in

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REFILE-UPDATE 8-UBS traders charged, bank fined $1.5 bln in Libor scandal

* Hong Kong launches new investigation

* Two senior UBS traders criminally charged in U.S.

* UBS fined $1.5 billion - second-largest fine ever levied

on bank

* Penalty will widen UBS Q4 loss

ZURICH/NEW YORK Dec 19 (Reuters) - U.S. prosecutors charged

two former UBS traders with taking part in a

multi-year scheme to manipulate Libor and other benchmark

interest rates, making them the first individuals to be

criminally accused in the international scandal.

The charges against the two traders, Tom Hayes and Roger

Darin, resulted from a broad investigation into the activities

of more than a dozen banks in the setting of prices for Libor

and related rates.

A day after UBS agreed to pay $1.5 billion to regulators in

the United States, UK and Switzerland, the Hong Kong Monetary

Authority (HKMA) said the bank was being probed over its

submissions of interbank rates there, raising the risk it could

face more fines.

In settling with U.S., UK and Swiss authorities, UBS not

only paid one of the largest fines ever imposed on a bank, its

Japanese subsidiary pleaded guilty to one U.S. criminal count of

fraud relating to manipulation of benchmark rates, including the

yen Libor.

The Japanese subsidiary is where authorities allege much of

the manipulation of interest rates occurred, as employees of the

bank looked to profit on derivatives trades linked to the rates.

The bank could have more trouble in store in Asia. HKMA,

Hong Kong's de facto central bank, said in a statement early

Thursday in Asia that it had received information from overseas

regulatory authorities about possible misconduct by UBS

involving submissions for the Hong Kong Interbank Offered Rate

(Hibor) and other reference rates in the region.

UBS is the second large international bank to reach a

settlement with U.S. and UK authorities, and other settlements

are expected to follow in the next few months. In June Barclays

Plc agreed to pay $453 million in fines to settle

allegations its employees attempted to manipulate Libor rates.

The investigation and it findings - that attempts to

manipulate Libor were fairly widespread in the banking industry

- have cast doubts on the reliability of Libor as a benchmark

for setting interest rates. The probe has also raised questions

about why bank regulators were slow to uncover the manipulation,

which Reuters previously reported dated back to at least the

late 1990s.

"The bank's conduct was simply astonishing," Lanny Breuer,

who heads the U.S. Justice Department's criminal division, said

in announcing the settlement.

"Make no mistake - for UBS traders, the manipulation of

Libor was about getting rich."

While the bank will hope that the $1.5 billion settlement

with regulators in the U.S., UK and Switzerland will draw a line

under its penalties for its role in Libor manipulation, it

remains at risk of action from regulators elsewhere for possible

rate rigging.

As well as Hong Kong, there is an ongoing investigation in

Singapore into the possible manipulation of benchmark lending

and foreign exchange rates.

"We continue to work closely with various regulatory

authorities to resolve issues relating to the setting of certain

global benchmark interest rates. As we are currently in active

discussions with these authorities, we cannot comment further,"

said a spokesman for UBS in Hong Kong.

CRIMINAL CHARGES

The Justice Department charged Hayes and Darin with

conspiracy, according to a criminal complaint unsealed in U.S.

district court in Manhattan on Wednesday. Hayes was also charged

with wire fraud and an antitrust violation.

U.S. and UK investigators portrayed Hayes as a ringleader of

sorts for UBS' manipulation of rates.

The two men are both believed to be in Europe, according to

a U.S. official. Last week, British police arrested Hayes and

two other men in connection with the Libor probe. The two others

were Terry Farr and James Gilmour, both of whom worked at

interdealer broker RP Martin.

The $1.5 billion UBS penalty is the second largest ever

imposed on a bank, exceeded only by the $1.9 billion that HSBC

agreed to pay to settle U.S. charges in connection with

the laundering of drug cartel money.

"We deeply regret this inappropriate and unethical behavior.

No amount of profit is more important than the reputation of

this firm," said UBS Chief Executive Sergio Ermotti.

The criminal complaint against Hayes and Darin also detailed

how some former UBS employees are cooperating in the probe, in

exchange for a promise that they won't be prosecuted.

The cooperation agreements forged in the UBS case could

prove useful to U.S. and UK authorities as they move against

other individuals and other big banks.

U.S. prosecutors, for instance, are continuing to

investigate the activities of a number of former Barclays

derivatives traders based in New York who were dismissed from

the bank following an internal investigation into Libor

manipulation. So far, none of those former Barclays employees in

the United States have been charged with wrongdoing.

Libor and related benchmarks are used to set interest rates

for trillions of dollars worth of loans around the world,

ranging from home loans to credit cards to complex derivatives.

Authorities said traders could benefit on their derivatives

positions by nudging the prices for Libor up just small amounts,

as over time the payoffs added up. Already a number of civil

lawsuits have been filed in the U.S. by institutional investors

claiming they were harmed on trades because of the interest rate

rigging.

'NORMAL BUSINESS PRACTICE'

In legal filings, Britain's Financial Services Authority

(FSA) said UBS staff made "corrupt" payments to reward brokers

for helping to manipulate rates - expanding the scandal to

include bribery.

It said attempts to manipulate Libor and Euribor, its

European equivalent, were so widespread that every submission

UBS made over a six-year period from 2005 to 2010 was suspect.

At least 45 people at UBS were involved in the rigging,

which was discussed in internal chat forums and group emails but

never detected by compliance staff, despite five audits.

The FSA said a wide pool of people within UBS considered the

manipulation to be a "normal business practice."

In addition to traders trying to move the Libor rate up or

down to make money for themselves, senior managers at the Swiss

bank directed dealers to keep Libor submissions low during the

financial crisis to make the bank look stronger.

Documents filed by the FSA did not reveal the names of

individual participants, but a source familiar with the matter

identified Hayes as the FSA's "Trader A," who the regulator said

"embarked on a coordinated campaign" to influence the yen Libor

rate.

In 2006 Hayes told a junior submitter at UBS that he

"generally coordinate " with Darin and "skew the libors a

bit."

In early 2007, Darin trained another junior submitter and

told him the primary consideration for UBS's yen Libor

submissions was the requests from Hayes and other UBS traders.

The extent of the wrongdoing was highlighted in a series of

emails released by the FSA. The exchanges may indicate how

traders and brokers conspired to rig the rate while adopting

nicknames such as "Captain Caos," (sic) and calling each other

"superman," "hero" or "the three muscateers (sic)."

In one email, Trader A (Hayes) wrote to a broker, urging him

to keep the six-month yen Libor rate unchanged on the day.

Traders paid brokers as much as 15,000 pounds ($24,000) a

quarter for their help in rigging the rates.

It is the first time that brokers have been accused of

taking bribes to aid the manipulation. ICAP, the world's

largest interdealer broker, and rival RP Martin have suspended

employees in connection with the probe.

Until the rate-rigging scandal broke, Libor had been ignored

by regulators and left to the banks to police. From next year,

Britain's FSA will oversee it as part of a major overhaul.

The steep fine for UBS comes even as the bank has cooperated

with law-enforcement agencies. The bank said it received

conditional immunity from some regulators.

The investigation into UBS's trading shows that the

manipulation of the benchmark rates and illicit trading took

place over a much longer time period than previously thought

with the improper requests extending into June 2010, according

to the UBS settlement with the Justice Department.

'UNACCEPTABLE BEHAVIOR'

UBS will pay $1.2 billion to the Justice Department and the

U.S. Commodity Futures Trading Commission, 160 million pounds to

the FSA, and 59 million Swiss francs from its estimated profit

to Swiss regulator Finma.

The UK penalty is the largest in the history of the FSA and

more than double the 59 million pounds paid by Barclays.

UBS said the fines would widen its fourth-quarter net loss

but that it would not need to raise new capital.

UBS shares fell 0.3 percent in trading on Wednesday after

earlier hitting a 17-month high.

The reputational impact of the controversy may only emerge

next year.

"The only thing shareholders can do is keep a very close eye

on the money flows on the wealth management side," said Neil

Wilkinson, portfolio manager at Royal London Asset Management.

Source: http://news.yahoo.com/8-ubs-traders-charged-bank-fined-1-5-050453587--sector.html

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